By Hans-Joachim Böhm, Gisbert Schneider, Raimund Mannhold, Hugo Kubinyi, Gerd Folkers
The lock-and-key precept formulated by way of Emil Fischer as early because the finish of the nineteenth century has nonetheless now not misplaced any of its importance for the lifestyles sciences. the fundamental features of ligand-protein interplay could be summarized below the time period 'molecular attractiveness' and challenge the specificity in addition to balance of ligand binding. Molecular reputation is therefore a important subject within the improvement of lively ingredients, for the reason that balance and specificity confirm no matter if a substance can be utilized as a drug. these days, computer-aided prediction and clever molecular layout make a wide contribution to the consistent look for, e. g., more suitable enzyme inhibitors, and new options corresponding to that of pharmacophores are being constructed. An up to date presentation of an perpetually younger subject, this e-book is an crucial info resource for chemists, biochemists and pharmacologists facing the binding of ligands to proteins.
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Additional resources for Protein-Ligand Interactions: From Molecular Recognition to Drug Design
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Protein-Ligand Interactions: From Molecular Recognition to Drug Design by Hans-Joachim Böhm, Gisbert Schneider, Raimund Mannhold, Hugo Kubinyi, Gerd Folkers