By Darryl Leon, Scott Markel

ISBN-10: 1574444786

ISBN-13: 9781574444780

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C. Barker, B. Boeckmann, S. Ferro, E. Gasteiger, et al. 2005. The Universal Protein Resource (UniProt). Nucleic Acids Res 33, Database Issue:D154–9. 8. Sigrist C. J. , L. Cerutti, N. Hulo, A. Gattiker, L. Falquet, M. Pagni, A. Bairoch, and P. Bucher. 2002. PROSITE: A documented database using patterns and profiles as motif descriptors. Briefings in Bioinformatics 3:265–74. 9. , C. J. Sigrist, V. Le Saux, P. S. Langendijk-Genevaux, L. Bordoli, A. Gattiker, E. De Castro, P. Bucher, and A. Bairoch.

T. Jones. 2000. The PSIPRED protein structure prediction server. Bioinformatics 16:404–5. 69. Jones, D. T. 1999. Protein secondary structure prediction based on position-specific scoring matrices. J Mol Biol 292:195–202. 70. Jones, D. , W. R. Taylor, and J. M. Thornton. 1994. A model recognition approach to the prediction of all-helical membrane protein structure and topology. Biochemistry 33:3038–49. 71. Sonnhammer, E. L. , G. von Heijne, and A. Krogh. 1998. A hidden Markov model for predicting transmembrane helices in protein sequences.

The FT describes the features and syntax [28]. Although not all features involve patterns, many do. 5 of the FT. 565) The three databases are freely available. 2 REBASE Restriction enzymes are used to cleave both DNA strands at specific sites, described by patterns. For example, BamHI matches “GGATCC” and cleaves after the first G. MslI’s pattern “CAYNNNNRTG” contains the unknown N (any nucleotide) and the ambiguous R (A or G) and Y (C or T). The Restriction Enzyme database (REBASE) contains information about restriction enzymes and related proteins.

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In Silico Technologies in Drug Target Identification and Validation (Drug Discovery) by Darryl Leon, Scott Markel

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