By Davis L. Temple, Jr. (Eds.)

ISBN-10: 0841205361

ISBN-13: 9780841205369

ISBN-10: 084120683X

ISBN-13: 9780841206830

content material: views on antiallergic brokers / H.F. Hodson --
The mechanism of histamine unencumber from mast cells near to the motion of antiallergic medications / J.C. Foreman --
Structure-activity relationships in a brand new category of pyrimido[4,5-b]quinoline antiallergy brokers / T.H. Althuis, S.B. Kadin, L.J. Czuba, P.F. Moore, and H.-J. Hess --
the advance of phenylenedioxamic acids as power antiallergy brokers / Charles M. corridor and H.G. Johnson --
New, orally powerful chromone derivatives for the remedy of bronchial asthma / H. Cairns --
Antiallergic purinones : a profitable software of QSAR / K.R.H. Wooldridge --
Clinically potent 6-ethyl-3-(1H-tetrazol-5-yl)chromone (AA-344) / Akira Nohara --
Pyranenamines : a brand new sequence of powerful antiallergic compounds / K.M. Snader, L.W. Chakrin, R.D. Cramer, III, Y.M. Gelernt, C.K. Miao, D.H. Shah, B.M. Sutton, J.W. Venslavsky, and C.R. Willis --
the advance of antiallergic pyranenamine sequence : a QSAR luck tale / Richard D. Cramer, III, Kenneth M. Snader, Chester R. Willis, Lawrence W. Chakrin, Jean Thomas, and Blaine M. Sutton --
Oxatomide : the prototype of a chemical sequence of compounds inhibiting either the discharge and the results of allergic mediators / F. Awouters, C.J.E. Niemegeers, P.A. Janssen, M. Janssen, J. Vandenberk, L. Kennis, M. Van Der Aa, and A. Van Heertum --
Bronchodilators and different pharmacodynamic brokers / Davis L. Temple, Jr. --
Pathophysiologic derangements within the power obstructive pulmonary illnesses and pharmacologic law of airway functionality / Sanford Chodosh --
New points of [beta]-adrenergic bronchodilator medications / Carl Kaiser --
fresh recommendations in theophylline-like bronchodilator medicinal drugs / Richard J. Seidehamel and Davis L. Temple, Jr. --
customers for a prostaglandin bronchodilator / Charles V. Grudzinskas, Jerauld S. Skotnicki, Sow-Mei L. Chen, M. Brawner Floyd, Jr., William A. Hallett, Robert E. Schaub, Gerald J. Siuta, Allan Wissner, Martin J. Weiss, and Franz Dessy.

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Clin. exp. Immun. (1973). 13, 139. 25. P. A. J. Immun. (1975). 114, 886. 26. L. O. J. Physiol. (1958). 140, 272. 27. M. G. J. exp. Med. (1964). 120, 507. 28. W. Br. J. Pharmac. (1968). 34, 451. 29. B. Ann. Rev. Pharmac. (1974). 14, 343. 30. Van Breemen, C. Arch, int. physiol. biochem. (1969). 77, 710. 31. C. L Br J Pharmac (1973) 48 527 32. Kanno. , Cochrane Pharmac. (1973). 57, 1001. 33. , Komoto, S. & Yamasaka, H. Proc. Japan Acad. (1970). 46, 317. 34. W. A. J. ,(1972). 247, 6970. 35. L. D. Nature (1973).

A L T H u i s ET AL. o. 8 10 XXX 2 a a a a Highest dose tested at which the compound was inactive. Figure 6. ; ACS Symposium Series; American Chemical Society: Washington, DC, 1980. DRUGS AFFECTING THE RESPIRATORY SYSTEM 46 Alkoxy substitution: Since methoxy substitution has a favorable in­ fluence on activity, this lead was pursued (Figure 7). Introduction of both a 7- and 8-methoxy substituent in the same molecule enhanced potency dramatically. 007 mg/kg and comparison of complete dose response curves indicates it is 84 times more potent than D S C G .

Allergy (1975). 19, 122. H. J. Allergy clin. Immun. (1978). 62, 44. Ishizaka, K. Adv. Immun. (1976). 23, 1. , Kulczycki, A. & Metzger, H. J. Immun. (1975). 114, 158. , Berczi, I. & Froese, A. Immunochemistry (1976). 13, 329. , Mauser, L. & Ishizaka, K. J. Immun. (1975). 115, 1078. , Budman, D. & Lucky, P. Immunochemistry (1976). 13, 417. Mendoza, G. & Metzger, H. Nature (1976). 264, 548. Mendoza, G. & Metzger, H. Nature (1976). 264, 550. , Rossi, G. & Metzger, H. Proc. Natl. Acad. Sci. A. (1977).

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Drugs Affecting the Respiratory System by Davis L. Temple, Jr. (Eds.)

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