By Hans G. Vogel
ISBN-10: 3540423966
ISBN-13: 9783540423966
The swift growth in biology will proceed to alter the methodological method of drug discovery within the coming years. digital media will constantly support researchers to entry and proportion details. it really is, even if, changing into an increasing number of obvious that many younger pharmacologists have simply constrained education in classical pharmacological methodologies. those long-standing and nonetheless hugely suitable equipment are easily no longer on hand within the digital databases. Drug Discovery and Evaluation:Pharmacological Assays bridges this hole through comprehensively masking the pharmacological equipment which have been applied effectively for greater than 100 years in addition to the most recent technologies.The classical equipment and the latest applied sciences, multi functional book!The third version of this winning reference e-book includes an up to date collection of the main usually used assays for reliably detecting the pharmacological results of power medicines. results lined contain cardiovascular, analgesic, endocrine, psychotropic, breathing, renal, and immunomodulatory actions. all of the greater than one thousand assays includes a close protocol outlining the aim and cause of the tactic, a severe overview of the implications and their pharmacological and scientific relevance. moreover, animal versions of infrequent ailments are described.For this 3rd variation, all present chapters were revised and fully up-to-date. numerous assays have been extra: we're now publishing volumes. Sections which have been in particular enlarged comprise - Pharmacological assays in thrombosis and haemostasis (formerly referred to as task of blood constituents),- Antidiabetic job (includes thoroughly new chapters akin to Biochemical tools in Diabetology), - Anti-atherosclerotic job.
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Extra resources for Drug Discovery and Evaluation
Sample text
927 Acute experimental pancreatitis . . . . . . . . . . . . . . . . . . . . . 931 Taurocholate-induced pancreatitis in the rat . . . . . . . . . . . . . . 933 Chronic pancreatitis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Liver function . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 936 Hepatocellular function . . . . . . . . . . . . .
Chronic gastric fistula in rats . . . . . . . . . . . . . . . . . . . . . . . Chronic gastric fistula in dogs . . . . . . . . . . . . . . . . . . . . . . . Heidenhain pouch in dogs . . . . . . . . . . . . . . . . . . . . . . . . . Gastrin activity . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Receptor binding for gastrin . . . . . . . . . . . . . . . . .
Inhibition of lipid peroxidation of isolated plasma low density lipoproteins . . . . . . . . . . . . . . . . . . . . . . . . . . . . Internalization of labeled LDL into HepG2 cells . . . . . . . . . . 3 Start XXXV 1115 1116 1117 1123 1123 1123 1124 Index XXXVI Contents Chapter N Endocrinology ............................................................................ 1 Endocrine survey .........................................................
Drug Discovery and Evaluation by Hans G. Vogel
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