By Binghe Wang, Longqin Hu, Teruna J. Siahaan
ISBN-10: 0471474894
ISBN-13: 9780471474890
An essential software for these operating on the entrance traces of latest drug developmentWritten for busy pros on the vanguard of recent drug improvement, Drug supply will get readers quick up to the mark on either the rules and newest functions within the more and more very important box of drug delivery.Recent advancements in such parts as combinatorial chemistry, proteomics, and genomics have revolutionized researchers' skill to speedily determine and synthesize new pharmacological compounds. although, delivery-related houses stay an important reason behind scientific trial failures.Bringing jointly contributions by way of prime overseas specialists, Drug supply covers the whole box in a scientific yet concise method. It starts off with an in-depth overview of key basics, similar to physiochemical and organic obstacles; drug supply pathways; metabolism; drug formula; pharmacokinetic and pharmacodynamic concerns; and extra. the rest of the booklet is dedicated to the systematic examination-including overviews, well timed examples, and large references-of a bunch of particular topics, including:* Receptor-mediated drug supply* Prodrug supply techniques* Oral protein and peptide drug supply* Gene remedy and gene supply* Ultrasound-mediated drug supply* Polycationic peptides and proteins in drug supply* Pulmonary drug supply* Antibody-directed drug supply* Efflux transporters in drug excretion* highbrow estate matters in drug supply
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Additional info for Drug Delivery: Principles and Applications (Wiley Series in Drug Discovery and Development)
Sample text
1. Importance of Drug Delivery to the Central Nervous System (CNS) Most drugs produce their required pharmacological response by altering cell function or structure in a concentration-dependent and reversible manner. Unless the target tissue is the blood and the drug is given intravenously or intra-arterially, the pharmacological response is dependent on the distribution of the drug to the target tissue in therapeutically relevant concentrations for sufficient periods of time to produce the clinically desired response.
B. Adv. Drug Deliv. Rev. 2001, 50, S41–S67. ; Tamai, I. Pharm. Res. 1996, 13, 963–977. Charman, W. ; Porter, C. ; Dressman, J. B. J. Pharm. Sci. 1997, 86, 269–282. Engman, H. ; Artursson, P. J. Pharm. Sci. 2001, 90, 1736–1751. Wacher, V. ; Benet, L. Z. Adv. Drug Deliv. Rev. 2001, 46, 89–102. ; Pang, K. S. Drug Metab. Dispos. 2000, 28, 224–235. Benet, L. ; Silverman, J. ; Wacher, V. J. J. Contr. Rel. 1999, 62, 25–31. ; Sugiyama, Y. Eur. J. Pharm. Sci. 2000, 12, 3–12. ; Langguth, P. Adv. Drug Deliv.
53,54 However, with a plasma half-life on the order of seconds,55 the effects of bradykinin on BBB permeability are short-lived, requiring carotid artery infusion. 56 This, coupled with the B2 receptor selectivity of Cereport, provides for a more consistent and reproducible effect on BBB permeability without many of the toxic side effects observed with bradykinin (see Ref. 57 for review). 66 Although Cereport appears to have greater effects on the brain microvasculature in and around the tumor site, it has also been used to increase BBB permeability in conditions other than brain tumor therapy.
Drug Delivery: Principles and Applications (Wiley Series in Drug Discovery and Development) by Binghe Wang, Longqin Hu, Teruna J. Siahaan
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