By Krishnendu Chakrabarty

ISBN-10: 1439819157

ISBN-13: 9781439819159

Microfluidics-based biochips mix electronics with biochemistry, offering entry to new software parts in a wide selection of fields. endured technological concepts are necessary to assuring the longer term function of those chips in useful diversification in biotech, prescribed drugs, and different industries.

Revolutionary counsel on layout, optimization, and trying out of inexpensive, disposable biochips
Microfluidic Biochips: layout Automation and Optimization comprehensively covers the suitable layout instruments and in-system automation equipment that might support clients adapt to new know-how and growth in chip layout and production. according to effects from numerous Duke collage examine tasks on layout automation for biochips, this publication makes use of real-life bioassays as examples to put out an automatic layout movement for developing microfluidic biochips. It additionally develops strategies to the original difficulties linked to that procedure.

Highlights the layout of the protein crystallization chip to demonstrate some great benefits of automatic layout flow
In addition to protecting automatic layout, the authors offer a close technique for the checking out, use, and optimization of sturdy, low-priced, manufacturable electronic microfluidic platforms utilized in protein crystallization and different components. The useful instruments and practices offered right here may help readers to:

  • Address optimization difficulties on the topic of structure, synthesis, droplet routing, and trying out for electronic microfluidic biochips
  • Make routing-aware, architectural-level layout offerings and defect-tolerant actual layout judgements simultaneously
  • Achieve the optimization target, consisting of minimizing time-to-response, chip sector, and attempt complexity
  • Effectively take care of functional matters resembling defects, fabrication price, actual constraints, and application-driven design

The authors current really expert pin-constrained layout suggestions for making biochips with a spotlight on fee and disposability. in addition they talk about chip trying out to make sure dependability, that is key to optimizing safety-critical purposes equivalent to point-of-care clinical diagnostics, on-chip DNA research, automatic drug discovery, air-quality tracking, and food-safety checking out. This ebook is an optimum reference for tutorial and business researchers within the components of electronic microfluidic biochips and digital layout automation.

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Additional info for Digital Microfluidic Biochips: Design Automation and Optimization

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18. , T. Mukherjee, and S. Hauan, Synthesis of multiplexed biofluidic microchips, IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems, vol. 2, pp. 321–333, 2006. 19. htm. 20. D. thesis, Duke University, Durham, NC, 2006. 21. , D. F. Cui, C. Liu, H. Li, and J. Chen, Continuous flow microfluidic device for cell separation, cell lysis and DNA purification, Analytica Chimica Acta, vol. 584, pp. 237–243, 2007. 22. €B. €D. Shenderov, Electrowetting-based actuation of liquid droplets for microfluidic applications, Applied Physics Letters, vol.

Digital microfluidic biochips are fabricated using standard microfabrication techniques [9]. Due to the underlying mixed technology and multiple energy domains, they exhibit unique failure mechanisms and defects. A manufactured microfluidic array may contain several defective cells. Defects observed include dielectric breakdown, shorts between adjacent electrodes, and electrode degradation [28]. Reconfiguration techniques can be used to bypass faulty cells or faulty optical detectors to tolerate manufacturing defects.

Luft, J. , D. M. Rak, and G. T. DeTitta, Microbatch macromolecular crystallization in micropipettes, Journal of Crystal Growth, vol. 196, pp. 450–455, 1999. 44. htm. 45. asp. 46. com. 47. Stevens, R. , High-throughput protein crystallization, Current Opinion in Structural Biology, vol. 10, pp. 558–563, 2000. 48. Krupka, H. , B. Rupp, B. W. Segelke, T. P. Lekin, D. Wright, H. C. €Todd, and A. Azarani, The high-speed Hydra-Plus-One system for automated highthroughput protein crystallography, Acta Crystallographica, vol.

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Digital Microfluidic Biochips: Design Automation and Optimization by Krishnendu Chakrabarty


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