By Sandeep Kumar, Satish Kumar Singh

ISBN-10: 1482246155

ISBN-13: 9781482246155

Biopharmaceuticals are rising as frontline medications to strive against numerous life-threatening and protracted illnesses. even if, such medications are dear to increase and bring on a advertisement scale, contributing to emerging healthcare charges. Developability of Biotherapeutics: Computational Approaches describes functions of computational and molecular modeling thoughts that increase the general strategy of discovery and improvement by way of removal empiricism.

The proposal of developability comprises making rational offerings on the pre-clinical phases of biopharmaceutical drug improvement which could certainly effect scientific results. The publication additionally addresses a basic lack of understanding of the various diverse contributions that computation could make to biopharmaceutical drug development.

This informative and sensible reference is a useful source for pros engaged in commercial learn and improvement, scientists operating with regulatory organizations, and pharmacy, medication, and existence technology scholars and educators. It focuses totally on the developability of monoclonal antibody applicants, however the ideas defined is also prolonged to different modalities reminiscent of recombinant proteins, fusion proteins, antibody drug conjugates and vaccines.

The e-book is geared up into sections. the 1st discusses ideas and functions of computational methods towards gaining knowledge of and constructing biopharmaceutical medications. the second one offers most sensible practices in developability checks of early-stage biopharmaceutical drug candidates.

In addition to elevating understanding of the promise of computational learn, this booklet additionally discusses ideas required to enhance the luck fee of translating biologic drug applicants into items on hand within the health facility. As such, it's a wealthy resource of data on present ideas and practices in addition to a place to begin for locating cutting edge functions of computation in the direction of biopharmaceutical drug development.

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H. Freeman, 1993. E. Hastedt, eds. Protein Formulation and Delivery. , vol. 175.  351. M. Chemical considerations in protein and peptide stability. In Protein Formulation and Delivery, ed. J. E. Hastedt. , vol. 175. New York: Informa Healthcare, 2008. , X. K. Singh. Identification and impact of aggregationprone regions in proteins and therapeutic monoclonal antibodies. In Aggregation of Therapeutic Proteins.  103–18. , et al. Aggregation in protein-based biotherapeutics: Computational studies and tools to identify aggregation-prone regions.

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Developability of biotherapeutics : computational approaches by Sandeep Kumar, Satish Kumar Singh

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