By Herbert Waldmann, Petra Janning
Conserving the confirmed didactic suggestion of the winning "Chemical Biology - studying via Case Studies", this sequel positive aspects 27 new case stories, reflecting the speedy development during this interdisciplinary subject during the last few years.
Edited via of the world's major researchers within the box, this textbook introduces scholars and researchers to the fashionable ways in chemical biology, in addition to very important effects, and the strategies and techniques utilized. each one bankruptcy offers a special organic challenge taken from daily lab paintings, elucidated by way of a global crew of well known scientists.
With its vast insurance, this can be a precious resource of data for college kids, graduate scholars, and researchers engaged on the borderline among chemistry, biology, and biochemistry.
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Extra info for Concepts and Case Studies in Chemical Biology
Rather than detailing the ﬁndings of the diﬀerent studies, this chapter will focus on the structure-based design of FLiK and FLiP protein constructs to enable these assays and their application in screening initiatives. 2 The Chemical Approach will serve as the attachment point for a thiol-reactive ﬂuorophore. The kinase mutant is then expressed, puriﬁed, labeled, and characterized using standard biochemical and biophysical methods. Although this may seem somewhat straightforward, it is necessary to have a strategy in place when designing the protein construct.
I. t. Rab Rac RANKL RAR Ras RCAR RDF REP rheb Rho Rhod RIKEN RMS RNA RNAi RNAPII RNase RNA-seq ROS RT-PCR S1P salph SAM Protein structure similarity clustering Protein Ser/Thr kinase Protein Ser/Thr phosphatase Positive transcription elongation factor Pancreas transcription factor Post-translational modiﬁcation Protein tyrosine phosphatase p-Toluenesulfonic acid Polyvinylidene diﬂuoride Benzotriazole-1-yl-oxy-tris-pyrrolidino-phosphonium hexaﬂuorophosphate PYR like 1-(2-Maleimidylethyl)-4-(5-(4-methoxyphenyl)oxazol2-yl)pyridinium methanesulfonate Pyrabactin resistance Quadrupole mutant Intra-peritoneal injection once a day Quantitative PCR Quantitative RT-PCR Room temperature Ras related in brain Ras-related C3 botulinum toxin substrate Receptor activator of NF-κB ligand Retinoic acid receptor Rat sarcoma Regulatory component of ABA receptors Recognition-domain focused sensors Rab escort protein Ras homolog enriched in brain Ras homologous Rhodamine B Rikagaku Kenkyusho (Institute of Physical and Chemical Research, Japan) Root mean square Ribonucleic acid RNA interference RNA polymerase II Ribonuclease RNA sequencing Reactive oxygen species Real time PCR Sphingosine-1-phosphate N,N-o-bis(3,5-di-tert-butylsalicylidene)–1,2phenylenediamine Simplest active molecule Abbreviations SAR SAS SDS SF SFV SHED shRNA SILAC siRNA SLO SMER snRNP Sortin sox SPPS SPR SR Src SRSF SSA ssDNA StAR protein START protein STAT3 StAx STF SylA TAMRA TBTA TBTU tBu TCEP TCF TCPTP TEF TEV TFA TGF TGN THF tmRNA TNF TNKS TNT Structure activity relationship Simplest active subgraph Sodium docecylsulfate Splicing factor Semliki forest virus Shannon entropy descriptor Small hairpin RNA Stable isotope labeling by amino acids in cell culture Small interfering RNA Streptolysine O Small molecule enhancers of rapamycin Small ribonuclear particles SORTing inhibitor Sry-box transcription factor Solid phase peptide synthesis Surface plasmon resonance Serine rich Rous sarcoma oncogene cellular homolog Serine/arginine splicing factor Spliceostatin A Single stranded DNA Steroidogenic acute regulatory protein StAR-related lipid transfer protein Signal transducer and activator of transcription 3 Axin-derived stapled peptide Super-topﬂash Syringolin A Tetramethyl-6-carboxyrhodamine Tris-(benzyltriazolylmethyl)amine O-Benzotriazole-1-yl-1,1,3,3-tetramethyluronium tetraﬂuoroborate tert-Butyl Tris(2-carboxyethyl)phosphine T-cell factor T-cell PTP Transcription elongation factor Tobacco etch virus Triﬂuoro acetic acid Transforming growth factor Trans-Golgi network Tetrahydrofurane Transfer-messenger RNA Tumor necrosis factor Tankyrase Trinitrotoluene XXXIX XL Abbreviations TO TOP2 TOS TosOMe TRAP+ TrCP Trt TSS UAS UPS UTP UV V-ATPase VCP VEGF VopS Vps34 vRNP VSR Wnt WPD-loop wt XN Y2H YFP Yip3 YPT δTIP Thiazole orange Topoisomerase II Target oriented synthesis para-Toluenesulfonic acid methyl ester Tartrate-resistant acid phosphatase-positive Transducing repeat-containing protein Trityl Transcriptional start site Upstream activating sequence Ubiquitin proteasome system Uridine triphosphate Ultra violet Vacuolar ATPase Valosin-containing protein Vascular endothelial growth factor Vibrio outer protein S Vacuolar protein sorting 34 Viral ribonucleoprotein Vacuolar sorting receptor Wingless and INT Trp-Pro-Asp loop Wild type Xanthohumol Yeast-2-hybrid Yellow ﬂuorescent protein YPT-interacting protein 3 Yeast protein transport Delta-tonoplast intrinsic protein 1 1 Real-Time and Continuous Sensors of Protein Kinase Activity Utilizing Chelation-Enhanced Fluorescence Laura B.
KGaA. Published 2014 by Wiley-VCH Verlag GmbH & Co. KGaA. 2 1 Real-Time and Continuous Sensors of Protein Kinase Activity cancer, neurodegenerative diseases, and metabolic disorders [3, 4]. Accordingly, much eﬀort has been put forth toward understanding kinase structure, function, and activity as well as toward the clinical development of kinase inhibitors for the treatment of human disease. Of considerable value to the scientiﬁc community are methods to study kinase activity, providing a means to evaluate kinase activity dynamics, inhibitor activities, and roles in cell signaling.
Concepts and Case Studies in Chemical Biology by Herbert Waldmann, Petra Janning