By Eric Francotte, Wolfgang Lindner, Raimund Mannhold, Hugo Kubinyi, Gerd Folkers
Chapter 1 Chiral medicines from a old perspective (pages 1–26): Joseph Gal
Chapter 2 Stereoselective Synthesis of substances – An business viewpoint (pages 27–65): Hans?Jurgen Federsel
Chapter three elements of Chirality in average items Drug Discovery (pages 67–94): Philipp Krastel, Frank Petersen, Silvio Roggo, Esther Schmitt and Ansgar Schuffenhauer
Chapter four Biotransformation tools for getting ready Chiral medicinal drugs and Drug Intermediates (pages 95–123): Michael Muller and Marcel Wubbolts
Chapter five answer of Chiral medicines and Drug Intermediates by means of Crystallisation (pages 125–154): Kazuhiko Saigo and Kenichi Sakai
Chapter 6 Isolation and creation of Optically natural medicines through Enantioselective Chromatography (pages 155–187): Eric Francotte
Chapter 7 Stereoselective Chromatographic tools for Drug research (pages 189–260): Norbert M. Maier and Wolfgang Lindner
Chapter eight Capillary Electrophoresis Coupled to Mass Spectrometry for Chiral medications research (pages 261–281): Serge Rudaz and Jean?Luc Veuthey
Chapter nine robust Chiral Molecular instruments for practise of Enantiopure Alcohols and Simultaneous decision in their Absolute Configurations by way of X?Ray Crystallography and/or 1H NMR Anisotropy equipment (pages 283–321): Nobuyuki Harada
Chapter 10 keyword phrases in Chirality Modeling: Molecular Modeling of Chirality – software program and Literature learn on Chirality in Modeling, Chirality in Docking, Chiral Ligand–Receptor interplay and Symmetry (pages 323–340): Gerd Folkers, Mine Yarim and Pavel Pospisil
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Additional resources for Chirality in Drug Research, Volume 33
Since this pioneering example, the field of asymmetric synthesis has seen remarkable development, and new improvements are still being added to the current arsenal of methodologies. The areas where most applications can be found are the pharmaceutical and fine-chemicals industries [9–13], but superb examples are also seen in agrochemistry , with its much tougher price competition and Fig. 2 The industrial breakthrough for asymmetric catalysis: Monsanto’s L-Dopa process. Performance data for the asymmetric step: TON (turnover number) = 206103, TOF (turnover frequency) = 103 h–1.
Cushny, Biological Relations of Optically Isomeric Substances, The Williams and Wilkins Company, USA, 1926, p. 37. 53 L. Pasteur Compt. Rend. Acad. Sci. 1886, 103, 138. 54 A. R. Cushny, J. Pharmacol. Exper. Ther. 1920, 15, 105–27. 55 P. J. Ramberg, Chemical Structure, Spatial Arrangement, The Early History of Stereochemistry, 1874–1914, Ashgate Publishing Limited, UK, 2003, pp. 268–272. 56 T. Sasaki and J. Kinose, Biochem. Z. 1921, 121, 171–4. 57 See Ref. 52, pp. 18–29. 58 See Ref. 52, p. 34. 59 N.
77 I. W. , Marcel Dekker, New York, 1993. 78 A. J. Hutt, S. C. Tan, Drugs, 1996, 52, Suppl. 5, 1–12. 79 M. Eichelbaum, A. S. Gross, Adv. Drug. Res. 1996, 28, 1–64. 80 P. Jenner, B. Testa, Drug Metab. Rev. 1973, 2, 117–184. 81 A. Burger, Introduction: History and Economics of Medicinal Chemistry, in M. E. , John Wiley & Sons, New York, 1980, p. 7. -m. Hsueh, C. S. Marvel, J. Am. Chem. Soc. 1928, 50, 855–859. 83 J. R. Powell, J. J. Ambre, I. R. Tsuen, The Efficacy and Toxicity of Drug Stereoisomers, in Ref.
Chirality in Drug Research, Volume 33 by Eric Francotte, Wolfgang Lindner, Raimund Mannhold, Hugo Kubinyi, Gerd Folkers