By Gerard Drewes, Marcus Bantscheff

ISBN-10: 1617793639

ISBN-13: 9781617793639

The multidisciplinary technology of chemical proteomics reviews how small molecules of man-made or normal starting place bind to proteins and modulate their functionality.  In Chemical Proteomics: tools and Protocols, professional researchers within the box supply key concepts to enquire chemical proteomics targeting analytical concepts, how probes are generated, thoughts for the invention of small molecule ambitions and the probing of aim functionality, and small molecule ligand and drug discovery.  Written within the hugely winning equipment in Molecular Biology™ sequence layout, chapters comprise introductions to their respective themes, lists of the mandatory fabrics and reagents, step by step, comfortably reproducible laboratory protocols, and key pointers on troubleshooting and averting recognized pitfalls.  Authoritative and useful, Chemical Proteomics : equipment and Protocols seeks to supply methodologies that might give a contribution to a much broader software of chemical proteomics tools in biochemical and telephone organic laboratories.

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Extra resources for Chemical Proteomics: Methods and Protocols (Methods in Molecular Biology, v803)

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17, 686–694. 14. , Savitzki, M. , Michon, A. M. , and Drewes, G. (2011) Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes. Nat. Biotechnol. 29, 255–265. 15. , and Rankovic, Z. (2004) From magic bullets to designed multiple ligands. Drug Discov. Today 9, 641–651. 16. , and Hopf, C. (2008) Chemical and pathway proteomics: powerful tools for oncology drug discovery and personalized health care. Mol. Cell Proteomics. 7, 1887–1901. 17. , and Handa H. (2010) Identification of a primary 2 18.

10. Huang, S. , Mishina, Y. , Michaud, G. , Wilson, C. , Kirschner, M. , Finan, P. , Tallarico, J. , Porter, J. , and Cong, F. (2009) Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling. Nature 461, 614–620. 11. Fleischer, T. , Murphy, B. , Flick, J. , Terry-Lorenzo, R. , Gao, Z. , Willardsen, J. , and Boniface, J. J. (2010) Chemical proteomics identifies Nampt as the target of CB30865, an orphan cytotoxic compound. Chem. Biol. 17, 659–664. 12. , Jeffrey, K. , Chung, C. , Rice, C.

Silinski, M. , Barta, T. , Hughes, P. , Smith, E. , Spangenberg, A. , Hanson, G. , Pronk, G. , Haystead, T. , and Hall, S. E. (2010) Application of chemoproteomics to drug discovery: identification of a clinical candidate targeting hsp90. Chem. Biol. 17, 686–694. 14. , Savitzki, M. , Michon, A. M. , and Drewes, G. (2011) Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes. Nat. Biotechnol. 29, 255–265. 15. , and Rankovic, Z. (2004) From magic bullets to designed multiple ligands.

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Chemical Proteomics: Methods and Protocols (Methods in Molecular Biology, v803) by Gerard Drewes, Marcus Bantscheff


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