By Zhongping Tan, Lai-Xi Wang (eds.)
Glycans play an essential function in modulating protein constitution and serve as from involvement in protein folding, solubility and balance to law of tissue distribution, acceptance specificity, and organic task. they could act as either confident and adverse regulators of protein functionality, offering an extra point of keep watch over with admire to genetic and environmental conditions.Due to the complexity of glycosylated protein kinds, elucidating structural and useful details has been difficult job for researchers yet contemporary improvement of chemical biology-based instruments and methods is bridging those wisdom gaps. This e-book offers an intensive overview of the present kingdom of glycoprotein chemical biology, describing the advance and alertness of glycoprotein and glycan synthesis applied sciences for figuring out and manipulating protein glycosylation. Read more...
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119 The surface plasmon resonance (SPR) binding analysis of the interactions between the synthetic isomeric M6P glycoprotein glycoforms and the cation-independent mannose 6-phosphate receptor (CI-MPR) reveals that a single M6P moiety located at the low α-1,3-branch of the oligomannose context is sufficient for high-affinity binding to receptor CI-MPR, the presence of a M6P moiety at the up-branch of the oligosaccharide core is dispensable, and close proximity of two M6P-oligosaccharide ligands in the peptide/protein context is critical to achieve high affinity for the CI-MPR.
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Chemical biology of glycoproteins by Zhongping Tan, Lai-Xi Wang (eds.)