By H.-J. Senn, U. Kapp

This quantity includes the most complaints of the fourth foreign convention on "Cancer Prevention 2006," which used to be held in the course of February 16–18, 2006, in St. Gallen, Switzerland. Written through overseas specialists within the box, the e-book contains a entire replace at the most modern advancements within the upsurging fields of molecular biology and melanoma genetics and their interactions with scientific epidemiology and melanoma prevention at quite a few levels.

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In the last few years, interest in the chemotherapy of NSCLC has rapidly increased, mostly because a number of new drugs – including paclitaxel, docetaxel, vinorelbine, gemcitabine, topotecan, and irinotecan – have emerged as active against this tumor. A number of clinical studies were conducted to identify an ideal chemotherapy regimen for advanced NSCLC, but to date, there is no accepted standard of care. Currently, lung cancer therapy strategy is predominantly dependent on tumor stage and the performance status of the patient (ZochbauerMuller et al.

2001) carcinomas and 172 SCCs, and 353 hospital controls without malignant disease), genotype frequencies for GSTM1, GSTM3, GSTP1, and GSTT1 were determined by PCR/RFLP-based methods. While adjusted odds ratios (OR) indicated no significantly increased risk for lung cancer overall due to any single GST genotype, the risk alleles for GSTM1, GSTM3, and GSTP1, conferring reduced enzyme activity, were present at higher frequency in SCC- than among adenocarcinoma patients (Risch et al. 2001). This is consistent with a reduced detoxification of carcinogenic polycyclic aromatic hydrocarbons from cigarette smoke that are more important for the development of SCC than of adenocarcinoma.

We have investigated the effects of several polymorphisms in DNA repair genes on lung cancer risk including XPA (-4G/ 25 A), XPD (Lys751Gln and Asp312Asn), XRCC1 (Arg399Gln), APE1 (Asp148Glu), and XRCC3 (Thr241Met) (Popanda et al. 2004). Polymorphisms were analyzed in a case–control study including 463 lung cancer cases (among them 204 adenocarcinomas and 212 SCCs) and 460 tumor-free hospital controls. Genotypes were determined using PCR-based melting point analysis of sequence-specific probes (LightCycler technology).

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Cancer Prevention by H.-J. Senn, U. Kapp


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