By Meir Shinitzky
An up-to date evaluation of easy study on biomembranes. during this quantity, finest specialists within the box ponder crucial structural and sensible features of biomembranes: - Membrane Lipids and Aging
- Membrane-bound Enzymes
- Ion Channels in organic Membranes
- Anion Exchangers of Mammalian mobilephone Membranes
- range of delivery Mechanisms in Bacteria.
the amount is a wonderful complement to 'Biomembranes - actual Aspects', additionally edited by means of Meir Shinitzky. jointly those books supply a complete flooring for figuring out complicated physiological processes.
Meir Shinitzky, Ph.D., is a Professor of Biophysics within the division of Membrane learn and Biophysics, The Weizmann Institute of technology, Rehovot, Israel. due to the fact 1971, his learn has keen on a number of features of membrane constitution and dynamics. presently his major curiosity is in manipulation of membrane fluidity for scientific diagnoses and coverings. He has released largely and is said world wide as one of many top specialists within the more and more major box of biomembrane examine.
Chapter 1 Membrane Lipids and getting older (pages 1–82): Hilary R. Shmeeda, Elisabeth B. Golden and Yechexkel Barenholz
Chapter 2 Membrane?Bound Enzymes (pages 83–197): G. Lenaz and M. Degli Esposti
Chapter three Ion Channels in organic Membranes – common ideas (pages 199–296): Rami Rahamimoff, Simona Ginsburg, Gavriel Barkai, Boaz prepare dinner, Jackie Edry?Schiller, Igor Kaiserman, Alon Meir, Michal Roll, Mary Kate Worden and Nilly Yakir
Chapter four Anion Exchangers of Mammalian mobilephone Membranes (pages 297–327): Z. Ioav Cabantchik
Chapter five range of shipping Mechanisms in micro organism (pages 329–379): Bert Poolman, Douwe Molenaar and Wil N. Konings
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Extra info for Biomembranes: Structural and Functional Aspects
Metabolic Aspects of Age-Related Alterations in Membrane Lipid Composition Phospholipids Very few studies have addressed the changes that may take place in lipid composition as a function of aging at the metabolic level. Changes in rates of biosynthesis or degradation, altered transfer rates in and out of the cell, changes in the activity of lipid exchange proteins and changes in post-transfer modification or processing may lead to the observed age-related alterations in lipid composition (Fig.
Sphingosine and lysosphingolipids, breakdown products of SPM, have been shown recently to be biologically active, affecting cellular responses and may be involved in signal transduction (review by [150,267]). SPM turnover seems to have a role in inducing cell differentiation . Sphingomyelinase action and sphingosine inhibit protein kinase C and phorbol ester-induced cellular responses [217-2191. Diacylglycerol (DAG), which activates PKC, and sphingosine are metabolically linked in the PC:ceramide choline phosphotransferase pathway (Fig.
Mass movement is dependent on the level of the phospholipid transfer protein (PLTP). The specific activities of such proteins are in the range of 50-2,500 nmoles min-’ mg-’ . Markovska et al.  reported a correlation between PC level and phospholipid transfer activity in microsomes of rats. PC content and PL transfer activity increase in parallel till 11 months and then decline in males. In females, both increase till 16 months. They contend that PL transfer proteins may play a role in age-induced changes in membrane PL composition.
Biomembranes: Structural and Functional Aspects by Meir Shinitzky