By Dennis E Vance
Study at the biochemistry and molecular biology of lipids and lipoproteins has skilled extraordinary development within the final two decades, relatively with the belief that many alternative sessions of lipids play basic roles in illnesses similar to center illness, weight problems, diabetes, melanoma and neurodegenerative problems. The fifth variation of this e-book has been written with significant ambitions. the 1st aim is to supply scholars and lecturers with a complicated updated textbook protecting the key parts of present curiosity within the lipid box. The chapters are written for college students and researchers acquainted with the final options of lipid metabolism yet who desire to extend their wisdom during this sector. the second one goal is to supply a reference textual content for scientists who're approximately to go into the sector of lipids, lipoproteins and membranes and who desire to examine extra approximately this quarter of analysis. the entire chapters were generally up to date because the 4th variation seemed in 2002. Key good points: * Represents a bridge among the superficial insurance of the lipid box present in easy biochemistry textual content books and the hugely really expert fabric contained in clinical overview articles and monographs. * permits scientists to get to grips with fresh advancements with regards to their very own examine pursuits, and may aid scientific researchers and clinical scholars hold abreast of advancements in uncomplicated technological know-how which are very important for next scientific advances. * Serves as a common reference ebook for scientists learning lipids, lipoproteins and membranes and as a complicated and up to date textbook for lecturers and scholars who're conversant in the fundamental strategies of lipid biochemistry learn more... content material: sensible roles of lipids in membranes / William Dowhan, Mikhail Bogdanov, and Eugenia Mileykovskaya -- Lipid ameliorations of proteins / Anant okay. Menon -- Fatty acid and phospholipid metabolism in prokaryotes / Charles O. Rock -- Lipid metabolism in crops / Katherine M. Schmid and John B. Ohlrogge -- Oxidation of fatty acids in eukaryotes / Horst Schulz -- Fatty acid synthesis in eukaryotes / Hei Sook Sul and Stuart Smith -- Fatty acid desaturation and chain elongation in mammals / Makoto Miyazaki and James M. Ntambi -- Phospholipid biosynthesis in eukaryotes / Dennis E. Vance and Jean E. Vance -- Ether-linked lipids and their bioactive species / Thomas M. McIntyre, Fred Snyder, and Gopal ok. Marathe -- Lipid metabolism in adipose tissue / Ann V. Hertzel ... [et al.] -- Phospholipases / David C. Wilton -- The eicosanoids : cyclooxygenase, lipoxygenase, and epoxygenase pathways / William L. Smith and Robert C. Murphy -- Sphingolipids / Alfred H. Merrill, Jr. -- ldl cholesterol biosynthesis / Laura Liscum -- Metabolism and serve as of bile acids / Luis B. Agellon -- Lipid meeting into mobilephone membranes / Dennis R. Voelker -- Lipoprotein constitution / Ana Jonas and Michael C. Phillips -- meeting and secretion of triacylglycerol-rich lipoproteins / Jean E. Vance and Khosrow Adeli -- Dynamics of lipoprotein delivery within the circulatory method / Christopher J. Fielding and Phoebe E. Fielding -- Lipoprotein receptors / Wolfgang J. Schneider -- Lipids and atherosclerosis / Ira Tabas. summary: learn at the biochemistry and molecular biology of lipids and lipoproteins has skilled impressive development within the final twenty years, relatively with the belief that many alternative sessions of lipids play primary roles in illnesses equivalent to middle ailment, weight problems, diabetes, melanoma and neurodegenerative problems. The fifth variation of this publication has been written with significant targets. the 1st aim is to supply scholars and academics with a complicated up to date textbook masking the main parts of present curiosity within the lipid box. The chapters are written for college students and researchers acquainted with the overall strategies of lipid metabolism yet who desire to extend their wisdom during this region. the second one target is to supply a reference textual content for scientists who're approximately to go into the sphere of lipids, lipoproteins and membranes and who desire to examine extra approximately this zone of analysis. the entire chapters were largely up-to-date because the 4th variation seemed in 2002. Key gains: * Represents a bridge among the superficial assurance of the lipid box present in simple biochemistry textual content books and the hugely really good fabric contained in clinical evaluate articles and monographs. * permits scientists to familiarize yourself with contemporary advancements regarding their very own examine pursuits, and should aid scientific researchers and clinical scholars maintain abreast of advancements in easy technological know-how which are very important for next scientific advances. * Serves as a basic reference publication for scientists learning lipids, lipoproteins and membranes and as a sophisticated and up to date textbook for academics and scholars who're acquainted with the elemental innovations of lipid biochemistry
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Extra info for Biochemistry of lipids, lipoproteins and membranes : (5th edn.)
The X-ray crystal structure of E. coli outer membrane ferric hydroxamate uptake receptor (FhuA) contains bound lipopolysaccharide in 1:1 stoichiometric amounts . The acyl chains of the lipopolysaccharide are ordered on the protein surface approximately parallel to the axis of the -barrel along the half of the hydrophobic belt oriented toward the extracellular surface of the outer membrane. Numerous van der Waals interactions with surface-exposed hydrophobic residues are observed. The large polar head group of lipopolysaccharide makes extensive interactions with a cluster of eight positively charged residues on the surface of the barrel.
In chloroplasts, SecA-coupled ATPase activity is optimally stimulated in the presence of the neutral lipid DGalDG and the anionic phospholipid PG at a molar ratio of 8:2, consistent with the content of neutral and anionic lipids in the thylakoid membranes of higher plants (C. Sun, 2007). Moreover, the presence of neutral DGalDG is favored over the zwitterionic PE as a partner with PG. Functional roles of lipids in membranes 27 Non-bilayer-forming lipids are also required for protein translocation across the membrane of E.
Selectivity of protein–lipid interactions A specific phospholipid requirement has been determined for optimum in vitro reconstitution of function for more than 50 membrane proteins. If one considers specific lipid requirements for membrane association and activation of amphitropic proteins, the number is in hundreds. Integral membrane proteins fold and exist in a very complex environment and have three modes of interaction with their environment. The extramembrane domains are exposed to the water milieu, where they interact with water, solutes, ions, and water-soluble proteins.
Biochemistry of lipids, lipoproteins and membranes : (5th edn.) by Dennis E Vance