By Nikolai N. Korpan (auth.), Nikolai N. Korpan MD, PhD (eds.)
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Depending on the 16 N. N. ) Basics of Cryosurgery method of monitoring (Ultrasound, CT or MRI) the error is from 4 to 8 mm (36). Grampsas et al. (1995) have found that the necrotic area resulting from cryodestruction appeared much smaller than predicted by intraoperative ultrasound (17). Steed et al. (1997) studied a correlation between thermosensor findings and transrectal ultrasonography findings during prostate cryoablation. Two cryosurgeons, working together and blinded to the actual temperature, used sonographic observations to estimate the temperature until they believed that the gland was adequately frozen.
And Ablin et al. (2) elicited antibodies reactive with prostatic tissue in man, as demonstrated by the immunofluorescence technique. Further, Mochizuki (6) reported transfer of tumor-specific immunity by infusion of the cryoimmune lymphocytes to other rats, showing establishment of passive antitumor immunization. A number of clinical reports suggesting induction or stimulation of tumor-specific immune reaction in consequence of cryosurgery in man were published in the 1970s (1,5,11,13). The mechanism of action is still unknown, but apparently involves both humoral and cell-mediated immunity, the latter playing an important role in the tumor-specific immune reaction.
Two representative cases are demonstrated as follows: Case 1. Tongue cancer, recurrent, a 46-year-old male. A recurrent tumor on the left side, found November 1986 (Fig. 8A). Oil-bleo, 30 mg, was injected intratumorally and on the periphery of the tumor, and was immediately followed by cryosurgery. The result was complete cryoablation of the tumor and no recurrence since then, more than 14 years later, leaving a tissue defect but no tongue dysfunction (Fig. 8B). Total extirpation of the tongue was avoided.
Basics of Cryosurgery by Nikolai N. Korpan (auth.), Nikolai N. Korpan MD, PhD (eds.)