By Michael E. Aulton BPharm PhD FAAPS FSP FRPharmS, Kevin M.G. Taylor BPharm PhD FAAPS FRPharmS

Pharmaceutics is among the such a lot various topic parts in all of pharmaceutical technology. in short, it's involved in the medical and technological features of the layout and manufacture of dosage types or drugs. An realizing of pharmaceutics is for this reason important for all pharmacists and people pharmaceutical scientists who're concerned with changing a drug or a possible drug right into a drugs that may be brought appropriately, successfully and with ease to the patient.

Now in its fourth version, this best-selling textbook in pharmaceutics has been introduced thoroughly brand new to mirror the fast advances in supply methodologies via eye and injection, advances in drug formulations and supply equipment for detailed teams (such as kids and the elderly), nanomedicine, and pharmacognosy. even as the editors have striven to take care of the accessibility of the textual content for college kids of pharmacy, retaining the stability among being a definitely pitched introductory textual content and a transparent mirrored image of the kingdom of the art.

provides a logical, accomplished account of drug layout and manufacture
includes the technology of formula and drug delivery
designed and written for beginners to the layout of dosage forms
New to this edition
New editor: Kevin Taylor, Professor of scientific Pharmaceutics, university of Pharmacy, college of London.
Twenty-two new contributors.
Six new chapters masking parenteral and ocular supply; layout and management of medications for the kids and aged; the most recent in plant drugs; nanotechnology and nanomedicines, and the supply of biopharmaceuticals.
Thoroughly revised and up-to-date all through.

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Extra resources for Aulton's Pharmaceutics: The Design and Manufacture of Medicines

Example text

The following explains the basic physicochemical properties of solutions that lead to such observations. s olub ility Similar types of intermolecular force may contribute to solute–solvent, solute–solute and solvent– solvent interactions. The attractive forces exerted between polar molecules are much stronger, however, than those that exist between polar and non-polar molecules or between non-polar molecules themselves. Consequently, a polar solute will dissolve to a greater extent in a polar solvent, where the strength of the solute/ solvent interaction will be comparable to that between solute molecules, than in a non-polar solvent, where the solute/ solvent interaction will be relatively weak.

E. without regular molecular lattice arrangements), crystalline, anhydrous, at various degrees of hydration or solvated with other entrapped solvent molecules, as well as varying in crystal hardness, shape and size. In addition, many drug substances can exist in more than one form with different molecular packing arrangements in the crystal lattice. This property is termed polymorphism and different polymorphs may be prepared by manipulation of conditions of particle formation during crystallization such as solvent, temperature and rate of cooling.

Consequently, the formulator must be aware of these potential transformations which can result in undesirable modi ed product performance, even though routine chemical analyses may not reveal any changes. Reversion from metastable forms, if used, to the stable form may also occur during the lifetime of the product. In suspensions, this may be accompanied by changes in the consistency of the preparation which affects its shelf-life and stability. Such changes can often be prevented by additives, such as hydrocolloids and surface-active agents.

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Aulton's Pharmaceutics: The Design and Manufacture of Medicines by Michael E. Aulton BPharm PhD FAAPS FSP FRPharmS, Kevin M.G. Taylor BPharm PhD FAAPS FRPharmS

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