By Joao H. Bastos
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Extra info for Athlete Performance and Injuries
2004). , 2007). On the other hand, there are some aspects that need to be better investigated before antioxidant intervention, because its potential effects can depend on the nature of the antioxidant, its dose and the prevailing oxygen partial pressure (PO2) in the tissues. Carotenoids, for example, are an effective antioxidant under low PO2 conditions (Borek, 2004; Hermes-Lima, 2004; Ferreira and Matsubara, 1997); while under high PO2 they are less efficient and may even act as pro-oxidants due to auto-oxidation (Borek, 2004).
Ahmetov II, Khakimullina AM, Popov DV, Missina SS, Vinogradova OL, Rogozkin VA. Polymorphism of the Vascular Endothelial Growth Factor Gene (VEGF) and Aerobic Performance in Athletes. Hum Physiol 2008; 34(4):477-481. Akimoto AK, Miranda-Vilela AL, Alves PCZ, Pereira LCS, Lordelo GS, Hiragi CO, Silva ICR, Grisolia CK and Klautau-Guimarães MN: Evaluation of gene polymorphisms in exercise-induced oxidative stress and damage. Free Rad Res. 2010,44:322-331. Akyol O, Yanik M, Elyas H, Namli M, Canatan H, Akin H, Yuce H, Yilmaz HR, Tutkun H, Sogut S, Herken H, Özyurt H, Savas HA, Zoruglu SS.
2008), the variant alleles of the MTHFR gene could contribute, in the course of time, to a lower oxygen supply to the heart in those endurance athletes who exercise strenuously, reducing cardiovascular fitness and thus performance, since they have been associated with increased Hcy. In fact, MTHFR C677T polymorphism has been associated with a lower hemoglobin level in a healthy exercise-trained population (Fortunato et al. 2007). Moreover, hemolysis can occur as a result of mechanical trauma in the capillaries of runners’ feet 32 Ana Luisa Miranda-Vilela (Carlson and Mawdsley, 1986), which would compromise performance still more in carriers of these variants.
Athlete Performance and Injuries by Joao H. Bastos