By John J. Langone (Eds.)

ISBN-10: 0121820793

ISBN-13: 9780121820794

The seriously acclaimed laboratory typical, Methods in Enzymology, is likely one of the so much hugely revered guides within the box of biochemistry. when you consider that 1955, each one quantity has been eagerly awaited, usually consulted, and praised via researchers and reviewers alike. The sequence comprises a lot fabric nonetheless correct this day - really an important ebook for researchers in all fields of existence sciences

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Segal, T. F. Spande, and D. R. Davies, Proc. Natl. Acad. Sci. A. 69, 3689 (1972). ~49j. UrbaJn, M. Wikler, J. D. Franssen, and C. Collignon, Proc. Natl. Acad. Sci. A. 74, 5126 (1977). ~50R. C. Kennedy, J. L. Melnick, and D. R. Dreesman, Science 223, 930 (1984). 151 Looking back to early experiments on autoanti-idiotypic antibodies, 7 internal images appear not to be found among such autoanti-idiotypic antibodies. Furthermore, when the Ab3 response induced by Ab2s was analyzed, the Abl antibodies expressed only the cross-reactive major idiotype characteristics for the normal response.

82, 1242 (1985). 8o T. Tai, L. D. Cahan, T. Tsuchida, R. E. Saxton, R. F. Irie, and D. L. Morton, Int. J. Cancer 35, 607 (1985). 81 T. Tai, J. C. Paulson, L. D. Cahan, and R. F. Irie, Proc. Natl. Acad. Sci. A. 80, 5392 (1983). 82 T. C. Meeker, J. Lowder, D. G. Maloney, R. A. Miller, K. Thielamane, R. Warnke, and R. Levy, Blood 65, 1348 (1985). 83 R. A. Miller, D. G. Maloney, R. Warnke, and R. Levy, N. Engl. J. Med. 306, 517 (1982). 16 IDIOTYPES, ANTI-IDIOTYPES, AND MOLECULAR MIMICRY [ll ness. The active immunotherapy of cancer patients with tumor-derived material includes various risk factors; above all, tumor-associated antigens (TAA) are often found to be poorly immunogenic.

L. Sacks, L. V. Kirchoff, S. Hieny, and A. Sher, J. lmmunol. 135, 4155 (1985). -L. Cheng, A. K. Sood, R. E. Ward, T. Kieber-Emmons, and H. K6hler, Mol. Immunol. 25, 33 (1988). -Y. Kang and H. KOhler, J. Exp. Med. 163, 787 (1986). 30 IDIOTYPES, ANTI-IDIOTYPES, AND MOLECULAR MIMICRY [1] tween nominal antigen and anti-Id does not ensure the complete structural identification of chemical-structural equivalence since different threedimensional environments can influence the folding patterns of related sequences.

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Antibodies, Antigens, and Molecular Mimicry by John J. Langone (Eds.)

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