By M. A. Christine Pratt (auth.), Grant N. Pierce, Volodymyr I. Mizin, Alexander Omelchenko (eds.)
The chance for publicity to harmful radiation, poisonous chemical substances within the setting and hostile organic brokers has elevated exponentially at the present time. The extra common and speedier commute that we event at the present time additionally escalates the danger of contraction and transmission of doubtless lethal infections. This has created a truly genuine and escalating danger for accidents and deaths. this is often accentuated within the army and scientific employees that's extra often uncovered to radiological, chemical, and organic brokers of their general operating setting. figuring out the mechanisms wherein those poisonous brokers inflict harm to bodies is vital to arrange us for those demanding situations. a lot of the wear and tear is inflicted in the course of the new release of unfastened radicals and non-radical oxidants which then act via oxidative mechanisms to damage the physique. This quantity will speak about the wear and tear as a result of those radiological, chemical, and organic environmental stressors, the mechanisms in which the wear can take place and the radical techniques that may be used to lessen the damage inflicted through those poisonous compounds. utilizing simple and medical examine techniques, the contents of this e-book speak about new rules for the improvement of bioactive items and environmental ways to reduce or negate the organic harm inflicted by means of those noxious compounds.
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Additional info for Advanced Bioactive Compounds Countering the Effects of Radiological, Chemical and Biological Agents: Strategies to Counter Biological Damage
Vitamin A can induce differentiation in certain normal and cancer cells, whereas BC and other carotenoids do not. Thus, BC and vitamin A have, in part, different biological functions. Therefore, both BC and vitamin A should be added to a multiple micronutrient preparation. The gradient of oxygen pressure varies within the cells. Some antioxidants, such as vitamin E, are more effective as quenchers of free radicals in reduced oxygen pressure, whereas BC and vitamin A are more effective in higher atmospheric pressures.
Konopacka M, Rzeszowska-Wolny J (2001) Antioxidant vitamins C, E and β-carotene reduce DNA damage before as well as after γ-ray irradiation of human lymphocytes in vitro. Mutat Res 491:1–7 27. Korkina LG, Afanas'ef IB, Diplock AT (1993) Antioxidant therapy in children affected by irradiation from the Chernobyl nuclear accident. Biochem Soc Trans 21(Pt 3):314S 28. Kulkarni SS, Ghosh S. Hieber K et al (2010) Radioprotective efficacy of γ-tocotrienol and pentoxifylline combination in murine model.
2 Drugs Approved by the FDA for Other Conditions These drugs include angiotensin converting enzyme inhibitors and statins. They provide significant tissue protection when administered after irradiation. The efficacy of these radioprotective drugs in reducing radiation damage was tested primarily on rodents (mice and rats). It is unknown whether these drugs would act as a mitigating Bio-Shield at doses that are safe in humans when consumed orally on a short- or long-term basis. These drugs satisfy only the first criterion of an ideal Bio-Shield; therefore, they cannot be used in humans for mitigating radiation injury at this time.
Advanced Bioactive Compounds Countering the Effects of Radiological, Chemical and Biological Agents: Strategies to Counter Biological Damage by M. A. Christine Pratt (auth.), Grant N. Pierce, Volodymyr I. Mizin, Alexander Omelchenko (eds.)