By D. J. Galas, T. B. L. Kirkwood, R. F. Rosenberger (auth.), T. B. L. Kirkwood, R. F. Rosenberger, D. J. Galas (eds.)

ISBN-10: 9400940971

ISBN-13: 9789400940970

ISBN-10: 9401083185

ISBN-13: 9789401083188

Molecular biology proceeds at unremitting velocity to spread new secrets and techniques of the dwelling international. Biology, lengthy considered as an inexact significant other to physics and chemistry, has passed through transformation. Now, chemical and actual rules are instruments in knowing hugely advanced biomolecular techniques, whose starting place lies in a background of probability, constraint and usual choice. The accuracy of those procedures, usually remarkably excessive, is important to their self­ perpetuation, either separately and jointly, as elements of the organism as a complete. during this booklet are offered 13 chapters which care for a number of features of the accuracy challenge. topics lined comprise: the specificity of enzymes; the constancy of synthesis of proteins; the replication and service of DNA: basic schemes for the enhancement of organic accuracy; choice for an optimum stability among the prices and advantages of accuracy; and the prospective relevance of molecular errors to the method of getting older. The viewpoints are detailed, but complementary, and the e-book as a complete deals to researchers and scholars the 1st entire account of this turning out to be field.

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Brown, P. , Kaufman, R. , and Slate, D. L. (1980) Chromosomal and extrachromosomal localization of amplified dihydrofolate reductase genes in cultured mammalian cells. Cold Spring Harbor Symp. Quant. , 45, 785-797. Schlesinger, M. , Ashbumer, M. and Tissieres, A. (eds) (1982) Heat Shock: From Bacteria to Man, Cold Spring Harbor Laboratory, New York. Thomas, P. G. and Mathews, M. B. (1984) Alterations of transcription and translation in Hela cells exposed to amino acid analogs. Mol. Cell. , 4,1063-1072.

D. Blackett), Brookhaven Symposium Volume 33, pp. 1-15. Holliday, R. (1986) Genes, proteins and cellular ageing. Benchmark Papers in Genetics (ed. R. Holliday), Nostrand Reinhold, Philadelphia. Holliday, R. and Kirkwood, T. B. L. (1983) Theories of cell ageing: A case of mistaken identity. 1. Theor. , 103, 329-330. Holliday, R. and Tarrant, G. M. (1972) Altered enzymes in ageing human fibroblasts. Nature, 238, 26-30. van: 33 34 Accuracy in Molecular Processes Hopfield, J. J. (1974) Kinetic proofreading: A new mechanism for reducing errors in biosynthetic processes requiring high specificity.

The problem is illustrated in Fig. 2, with two substrate concentrations [SI] and [S2] having respective rates VI and V2. 2 A reaction showing saturation kinetics has different rates, VI and Vz, at different substrate concentrations [SI] and [Sz] respectively. Enzyme-substrate interactions occurs at the Km for the reaction. This is shown as follows. 8) v~ -XVI)2 = VI + V2. e. at the Km of the reaction, and so the optimal physiological concentration of the substrate is at its Km (Fersht, 1974). (b) Specificity The kinetics of enzyme catalysed reactions can also yield interesting conclusions about specificity and accuracy.

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Accuracy in Molecular Processes: Its Control and Relevance to Living System by D. J. Galas, T. B. L. Kirkwood, R. F. Rosenberger (auth.), T. B. L. Kirkwood, R. F. Rosenberger, D. J. Galas (eds.)


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