By David G. Kleinbaum

ISBN-10: 0387459642

ISBN-13: 9780387459646

ISBN-10: 0387459669

ISBN-13: 9780387459660

A Pocket consultant to Epidemiology is a stand-alone introductory textual content at the simple ideas and ideas of epidemiology. the first viewers for this article is the general public healthiness scholar or expert, clinician, health and wellbeing journalist, and somebody else at any age or lifestyles adventure that's attracted to studying what epidemiology is all approximately in a handy, effortless to appreciate layout with well timed, real-world overall healthiness examples.

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An intention-to-treat analysis requires that the investigators "analyze what they randomize", that is, analysis should be compared to the originally randomized treatment groups, even if study subjects switch treatments during the study period. Summary ™ The major objective of a clinical trial is to test the efficacy of a preventive or therapeutic intervention. ™ Key features of any clinical trial are: Randomization Ethical concerns Blinding Intention to treat analysis Clinical Trial Example A clinical trial involving 726 subjects conducted in 1993 compared standard insulin therapy with intensive insulin therapy involving more frequent insulin injections and blood glucose monitoring for the treatment of diabetes mellitus.

X They are more susceptible to information bias than cohort studies because they are always backward in directionality. x They are not efficient for studying rare exposures Summary ™ Start with cases and non-cases of a disease or other health outcome and proceed backwards to determine prior exposure history. ™ Popular primarily because cheaper and less time-consuming than cohort studies. ™ Other advantages include providing sufficient numbers of cases for rare diseases with long latencies and allowing several exposures to be evaluated.

Appropriate for studying rare exposures: . . 10. Appropriate for studying rare diseases: . ??? 8. More accurate exposure information: 11. Can study multiple outcomes: . . 12. Requires a smaller sample size: . . ??? 13. Can estimate risk: . . . Determine whether each of the following statements is true or false: 14. Ideally, controls should be chosen from the same population that gave rise to the cases. . 15. Ideally, controls should be selected from hospitalized patients ??? 16. Population-based controls include only neighbors and persons identified by calling random telephone numbers.

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A Pocket Guide to Epidemiology by David G. Kleinbaum

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